The objective of this study was to develop sustained release matrix tablets of Metoprolol Succinate (MS) for oral delivery using Poly ethylene oxide (PEO) blended with other polymers such as Xanthan gum, Eudragit, Hydroxypropyl cellulose (HPC) & Hydroxy ethyl cellulose (HEC). Matrix tablets were prepared by Direct compression & wet granulation to fabricate drug containing polymeric granules in polymeric matrix after which they were characterized for physical characteristics. The effect of process variables such as; method of preparation, blending of PEO with other polymers, effect of adding diluent, drug loading, stirring speed , the effect of addition of HPMC K-100 and addition of electrolyte along with PEO as extra granular polymer on the release profile of drug was also evaluated. The drug- polymer interaction studies were performed by FTIR. The drug release data were analyzed by zero order, first order, Higuchi and Peppas equations. Finally it was concluded that by using proper combination of polymers, diluents & drug loading, Sustained release (SR) matrix tablet of MSsuitable for once a day could be easily prepared & commercialized.
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